EFFECT OF ACUTE INTOXICATION WITH AFLATOXIN B1 ON THE ANTIOXIDANT SYSTEM IN RED BLOOD CELLS AND LUNG CELLS OF WHITE RATS
Contamination of agricultural products with mycotoxins is a widespread phenomenon that is manifested in many countries. Among mycotoxins, which significantly affect human and animal health, aflatoxins produced by Aspergillus micromycetic fungi (mainly A. flavus) are of serious concern because of their high toxicity and carcinogenicity. The aim of our study was to investigate the effect of aflatoxin B1 (AFB1) on intracellular metabolism in laboratory animals. The dynamics of the lipid peroxidation (LPO) and activities of antioxidant system enzymes (superoxide dismutase, glutathione peroxidase, and glutathione reductase) in lung cells and erythrocytes of white rats were analyzed within 14 days after administration of AFB1 (dose 1/10 LD50). The results of the study have shown the activation of the LPO processes and a decrease in the activity of enzymes of the antioxidant system in the cells of rats of the experimental groups. In general, the obtained results suggest the development of oxidative stress in the lungs cells and erythrocytes of animals under the influence of aflatoxin B1.
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